Table 4.

Hematologic and hepatic toxicity table

Cat no.
Dose level (pfu/tumor)
Hematologic*
Hepatic
WGPltPCVALTALPAlbBili
1109SMoNMoNNMiN
2109MiMiNMoMiNNN
3109NNNNNNNN
41010MiMiMiMoMiNNMi
51010MoMoMiMoMiMiNMi
61010MoMoMiMoMiMiNMi
71010MiMiNNMiMiNMi
84 × 1010MiMiSSMoNMiS
94 × 1010MiMiMiMoNNMiMi
104 × 1010MoMiMiNNNNN
114 × 1010MiMiSSMiNMiMi
124 × 1010NNMiSNNSS
131010MiMiMiNMiNNN
  • NOTE: Blood investigations were done during the week of gene therapy and hyperthermia and the hematologic and hepatic toxicity graded in all cases for each parameter based on values outlined in Table 2.

  • Abbreviations: W, WBC; G, granulocytes; Plt, platelets; PCV, packed cell volume; ALT, alanine aminotransferase; ALP, alkaline phosphatase; Alb, serum albumin; Bili, total bilirubin; N, normal; Mi, mild toxicity; Mo, moderate toxicity; S, severe toxicity.

  • * Drop in granulocyte counts seen in all cases ∼48 to 72 h post-hyperthermia.

  • Case also had pulmonary edema.