Table 1.

Toxicity grading

SystemNormalMild toxicityModerate toxicitySevere toxicity
Hematologic
    WBC (×103/μL)5–173–52–3<2
    Granulocytes (×103/μL)4–102–41–2<1
    Platelets (×103/μL)150–50080–15040–80<40
    PCV (%)28–50NA15–28<15
Hepatic
    ALT (IU/L)17–5960–150151–400>400
    Alk. phos (IU/L)2–4041–120121–400>400
    Albumin (g/dL)2.8–4.52.2–2.81.8–2.2<1.8
    Bilirubin (mg/dL)0–0.20.2–2.02.0–2.5>2.5
  • NOTE: The hematologic and hepatic toxicity grading criteria used in this study for cats were based on values modified from the National Cancer Institute Common Toxicity Criteria version 2.0.

  • Abbreviations: PCV, packed cell volume; ALT, alanine aminotransferase; Alk. phos, alkaline phosphatase.