Table 1.

Differentially expressed genes in MCF-7 cells after prodigiosin treatment

Gene nameGenbank no.SwissProt no.RatioClassification
Up-regulated genes
    Interferon induced transmembrane protein 1 (9-27) (IFITM1)J04164P131642.06Cell cycle
    Cyclin-dependent kinase inhibitor 1 (CDKN1A/p21)U09579P38936>2Cell cycle
    Fms-related tyrosine kinase 1 (FLT1)X51602P17948>2Cell cycle
    Junction plakoglobin (JUP)M23410P14923>2Cell adhesion
    Ubiquitin-conjugating enzyme E2 17-kDa (UBE2A)M74524P49459>2Protein turnover
    Purine-rich ssDNA-binding protein α (PURA)M96684Q00577>2Transcription regulator and DNA replication
    Zinc finger protein 36 (ZFP36L1)X79067Q07352>2Transcription regulator
    Integrin β4 (ITGB4)X53587P16144>2Cell adhesion
    HLA-G histocompatibility antigen, class I, G (HLA-G)M32800Q30182>2Cellular defense response
    Procollagen (type III) N-endopeptidase (PCOLN3)U58048Q15779>2Cell cycle
    Teratocarcinoma-derived growth factor 3 (TDGF3)M96956P13385>2Cell differentiation
    Interleukin-1, β (IL1B)K02770P01584>2Cell cycle and apoptosis
    Cell division cycle 34 (CDC34)L22005P49427>2Protein turnover and cell cycle
    Nonsteroidal anti-inflammatory drug-activated gene 1/growth differentiation factor 15 (NAG-1/GDF15)AF019770Q9998811.72Cytokine activity, cell cycle and apoptosis
    RAN binding protein 2 (RANBP2)L41840P49792>2Trafficking/targeting protein
    Keratin 7 (KRT7)X03212P08729>2Cytoskeleton protein
    IFN-stimulated exonuclease gene 20 kDa (ISG20)U88964O00586>2Cell cycle
    Proteasome activator subunit 1 (PSME1)L07633Q06323>2Protein turnover
    Eukaryotic translation elongation factor 1α1 (EEF1A1)M27364Q142222.22Translation elongation
    Insulin-induced gene 1 (INSIG1)U96876O15503>2Metabolism
Down-regulated genes
    Deleted in colorectal carcinoma (DCC)X76132P43146<0.5Cell cycle and apoptosis
    v-myc myelocytomatosis viral oncogene homologue (MYC/c-myc)V00568P011060.36Cell cycle
    Notch homologue 4 (NOTCH4)U95299O00306<0.5Cell differentiation
    v-abl Abelson murine leukemia viral oncogene homologue 2 (ABL2)M35296P42684<0.5Oncogenes
    Prostaglandin E synthase (PTGES)AF010316O14684<0.5Metabolism
    Prohibitin 2 (PHB2)U72511Q99623<0.5Transcription regulator
    Guanylate kinase 1 (GUK1)L76200Q16774<0.5Metabolism
    Rho GDP dissociation inhibitor (GDI) α (ARHGDIA)X69550P525650.44Cell motility and apoptosis
    TNF receptor-associated protein 1 (TRAP1)U12595Q129310.43Apoptosis-associated proteins
    Retinoic acid receptor, γ (RARG)M24857P13631<0.5Transcription regulator
    Macrophage migration inhibitory factor (MIF)M25639P141740.47Apoptosis-associated proteins
    TIMP metallopeptidase inhibitor 1 (TIMP1)X03124P01033<0.5Cell cycle
    Vitronectin (VTN)X03168P04004<0.5Cell adhesion
    Keratin 8 (KRT8)M34225P057870.17Cytoskeleton protein
    Hemoglobin, α1 (HBA1)V00491P01922<0.5Trafficking/targeting proteins
    Keratin 18 (KRT18)M26326P05783<0.5Cytoskeleton protein
    Nonmetastatic cells 4, protein expressed in (NME4)Y07604O00746<0.5Metabolism