Table 1.

Calculated AUC0–24 of paclitaxel in blood and tissues (n = 3) after p.o. administration of 50 mg/kg DHP107 and i.v. administration of 10 mg/kg Taxol

DHP107 (50 mg/kg)
Taxol (10 mg/kg)
Bioavailability in organs (%)
Tmax (h)Cmax (μg/mL)AUC0–24 (μg·h/g)Tmax (h)Cmax (μg/mL)AUC0–24 (μg·h/mL)
Blood22.2 ± 0.1*10.4 ± 2.423.2 ± 3.19.1 ± 1.123
Liver263.5 ± 11.8363.7 ± 80.050.0 ± 2.867.6 ± 7.4108
Spleen47.7 ± 0.856.5 ± 6.20.51.7 ± 0.21.2 ± 0.3942
Kidney213.1 ± 2.783.0 ± 13.633.7 ± 1.223.6 ± 1.5070
Heart25.3 ± 1.336.4 ± 5.610.3 ± 1.77.7 ± 1.195
Lung212.2 ± 3.869.4 ± 17.419.9 ± 2.530.8 ± 5.145
Stomach0.52,637.1 ± 224.611,978.9 ± 2,296.20.53.2 ± 0.66.2 ± 1.138,642
Jejunum278.4 ± 17.0617.8 ± 102.00.510.6 ± 1.221.9 ± 3.6564
Ileum8112.7 ± 31.91,543.6 ± 392.715.5 ± 2.020.2 ± 4.31,528
Colon24113.12,097.4 ± 145.422.6 ± 0.316.1 ± 1.92,605
  • * SD.

  • Error could not be estimated (n = 1).