Table 2.

Induction of Nqo1 RNA transcripts in mouse tissues 6 h following gavage with triterpenoids (2 μmol/kg body weight)

Embedded Image
Fold change of Nqo1 RNA transcripts
TP #NameR1R2Small intestine mucosa
Liver
Lung
Cerebral cortex
1 dose1 dose3 doses1 dose3 doses1 dose3 doses
Carboxylic acid151CDDONCCO2H8.4*2.7*ne1.5ne1.3ne
Esters155CDDO-MeNCCO2Me7.5*5.6*12.4*4.7*5.1*1.5*1.9*
230NCCO2(CH2)3CH35.0*2.6ne1.7ne1.8*ne
222HO2CCO2Et1.80.9ne1.4ne1.3ne
Amides223NCCONH22.9*2.0ne2.1*ne1.7*ne
224NCCONHMe6.7*4.0*3.22.4*2.2*1.21.3
319NCCONHEt4.9*2.9*2.2*1.9*2.5*0.82.0*
226NCCONMe22.5*1.7ne1.6ne1.2ne
500NCCONH-CH2-CF32.61.73.1*1.01.8*0.82.0*
Imidazoles/pyrazole235CDDO-ImNCEmbedded Image9.5*8.6*3.4*3.5*2.0*1.42.0*
254NCEmbedded Image11.3*4.0*ne2.7*ne1.2ne
261NCEmbedded Image5.0*3.0*ne2.5*ne0.8ne
299NCEmbedded Image2.61.2ne2.0ne0.6ne
242NCEmbedded Image5.5*1.5ne2.2*ne0.6*ne
Dinitrile225NCCN5.3*4.9*4.3*3.6*4.0*1.5*2.0*
Oleanolic acidOAEmbedded Image0.81.0ne1.2ne1.3ne
  • * P < 0.05, n = 4 for vehicle group and n = 3 for all other groups.

  • Not evaluated (indicates that this dose and schedule was not tested).