Table 2.

Pharmacokinetic and blood clearance of EpCAM-targeted immunoliposomes (SIL-Dox) and nontargeted liposomes (SL-Dox) in tumor-bearing mice

LiposomeHalf-life (h)Clearance (mL/h/kg)AUCt = 0→α (μg·h/mL)Vd (mL/kg)
SL-Dox11.2 ± 0.44.8 ± 0.23,526 ± 14477.9 ± 3.6
SIL-Dox11.4 ± 0.25 ± 0.33,358 ± 23979.8 ± 2.0
  • NOTE: Mice bearing SW2 tumor xenografts (85–100 mm3) were injected i.v. with a single dose of 4 mg doxorubicin/kg (0.66 μmol phospholipid per mouse) encapsulated in liposomes labeled with [3H]CHE. Pharmacokinetic variables were determined using WinNonLin software. Data represent the mean ± SD (n = 3 mice per time point).

  • Abbreviations: AUC, area under the blood concentration versus time curve; Vd, volume of distribution.