Table 1.

IC50 values of various antimetabolic drugs in PC-6 and PC-6/FU23-26 cells

PC-6
PC-6/FU23-36
RR
IC50 (95% CI)IC50 (95% CI)
5-FU (μmol/L)0.78 (0.58–1.07)19.65 (4.20–91.99)25.2
Methotrexate (μmol/L)0.12 (0.09–1.71)6.28 (1.90–20.70)52.3
Gemcitabine (nmol/L)6.13 (2.31–16.20)3.75 (2.950–4.760)0.6
1-β-d-Arabinofuranosylcytosine (nmol/L)40.70 (29.30–56.40)36.20 (28.80–45.50)0.8
  • Abbreviation: RR, resistance ratio: (IC50 in resistant subline)/(IC50 in the parental cells).