Table 1.

Inhibition of in vivo angiogenesis by IB05204 and related compounds

Dose (nmol/CAM)IB05204Compound 1Compound 2Compound 3
00 (0/20)0 (0/20)0 (0/20)0 (0/20)
0.0520 (1/5)NDNDND
0.175 (3/4)NDNDND
0.2100 (4/4)NDNDND
0.5100 (3/3)NDNDND
1100 (3/3)ND0 (0/3)ND
2100 (4/4)0 (0/3)0 (0/3)ND
4100 (4/4)0 (0/3)0 (0/4)0 (0/4)
10100 (3/3)0 (0/4)0 (0/3)25 (1/4)
  • NOTE: CAM assay was carried out with different doses of the compounds as described in Materials and Methods. Data are given as percentage of inhibition. Between brackets, the number of eggs with inhibited angiogenesis in their CAMs per total number of treated egg CAMs is indicated.

    Abbreviation: ND, not determined.