Table 1.

Response of breast cancer cells to the cytostatic and cytotoxic effects of persin

Cell lineEstrogen receptor statusp53 statusBim status*Response to persin
Growth inhibitionApoptosisMicrotubule bundling
MCF-7+wt++++++++++
T-47D+mut+−−++++++
MDA-MB-231mut−−−
MDA-MB-157mut+−−+++++
MDA-MB-361+wt+−−+++++
Hs 578.Tmut−−−+
SK-Br3mut+++++++++
  • NOTE: Cell lines were treated with 27.6 μmol/L of persin for 24 hours (growth inhibition and apoptosis) or 13.8 μmol/L for 16 hours (microtubule bundling). Estrogen receptor, p53, and Bim status were determined by immunoblotting.

  • * BimEL, BimL, and BimS.

  • 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.

  • M30 positivity.