Table 3.

Doxorubicin intracellular accumulation

ScheduleIntracellular doxorubicin amount (%)*
MCF7MCF7 ADR
Control00
Doxorubicin 1 d100100
PB28 2 d then doxorubicin 1 d154 ± 5175 ± 6
Control00
Doxorubicin 1 d100100
PB28 1 d then PB28 and doxorubicin 1 d133 ± 3.5150 ± 5
  • NOTE: Cells were treated with PB28 and/or doxorubicin and the cytotoxic drug was evaluated by flow cytometry. Percent drug accumulation with respect to the control 1-day doxorubicin alone (%).

  • * Mean ± SE of three independent experiments.