Table 2.

Quantitative comparison of CPX-1 in vivo antitumor activity in the murine Colon 26 colon carcinoma model (treatment days 9, 13, and 17)

TreatmentDose (μmol/kg)TC (d)Log cell kill
Lipo-FX302.9 ± 0.90.7
Lipo-IT302.7 ± 0.30.6
CPX-130:3010.4 ± 0.92.5*
  • NOTE: Log cell kill = [TC / (3.32)(Td)], where TC is the treatment-induced delay for tumors to reach 500 mg (+SD, n = 6) and Td is the tumor doubling time.

  • * Statistically different (P < 0.001) from all other groups using Student-Newman-Keuls analysis.