Table 1.

Effect of NQO1 inhibitors on the rate of respiration in MIA PaCa-2 cells

TreatmentTimeO2 consumption*
Untreated03.1 ± 0.2
Dicumarol 100 μmol/L010.1 ± 0.3
ES936 100 nmol/L03.5 ± 0.3
Untreated1 h2.6 ± 0.5
Dicumarol 100 μmol/L1 h4.3 ± 0.5
ES936 100 nmol/L30 min2.19 ± 0.8
ES936 100 nmol/L1 h2.9 ± 0.6
  • * nmol O2/min/million cells; mean ± SD; n = 3 separate determinations.

  • P < 0.01 compared with untreated, one-way ANOVA using Dunnett's multiple comparison test.

  • P < 0.05 compared with untreated (1 hour), one-way ANOVA using Dunnett's multiple comparison test.