Table 4.

Ranking of CCT018159 analogues from the highest (top) to the lowest (bottom) AUC following cassette and single compound i.v. administration

Cassette
Individual*
Individual
AUClastAUCINFAUClastAUCINFAUClastAUCINF
CCT066965CCT066965CCT066965CCT066965CCT066965CCT066965
CCT066963CCT018159CCT066963CCT066963CCT018159CCT018159
CCT018159CCT066963CCT018159CCT018159CCT066963CCT066963
CCT066952CCT066952CCT066950CCT066950CCT066950CCT066950
CCT066950CCT066950CCT066952CCT066952CCT066952CCT066952
  • * Calculated up to the time of the last measurable concentration following cassette dosing.

  • Calculated up to the time of the last measurable concentration following single compound dosing.

  • CCT066950 was only detectable for up to 5 minutes following cassette dosing.