Table 2.

Parent loss of CCT018159 analogues following a 5-minute incubation at 10 ╬╝mol/L with mouse liver microsomes, human liver microsomes, and human intestinal microsomes

Compound% Parent loss
Mouse liver microsomesHuman liver microsomesHuman intestinal microsomes
CCT01815958.0 (3.40)85.565.3
CCT06695073.7 (2.48)43.70
CCT06695288.9 (2.43)74.826.4
CCT06696370.5 (1.33)43.233.6
CCT06696598.2 (0.23)96.789.9
  • NOTE: Mouse liver microsome incubations were done in triplicate. The SE is shown in parenthesis.