Molecular determinants of clinical outcome in pancreatic cancer
| Determinant | Correlation with clinical outcome | Rationale |
|---|---|---|
| Akt | P < 0.01 between p-Akt low expression and longer OS | Akt has antiapoptotic activity and favors angiogenesis and cancer invasiveness. |
| Tissue factor | P < 0.0001 between tissue factor low expression level and longer OS | Tissue factor expression correlates with invasiveness and angiogenesis. |
| mdm2 | P < 0.05 between mdm2 expression and shorter OS | The mdm2 oncogene product affects normal p53 function. |
| S100A6 | P = 0.003 between high nuclear S100A6 expression and shorter OS | S100A6 may be involved in promoting cancer growth, invasiveness, and metastasis. |
| EGFR | P = 0.02 between EGFR cytosolic overexpression and shorter OS | EGFR is involved in mitogenic signaling pathways. |
| Bax | P < 0.05 between Bax detection and longer OS | Bax gene is a promoter of apoptosis. |