Table 2.

CI values for the combination of 17-AAG and Taxol in cell lines

Cell lineExposure conditionsCI at fu0.5Average CI at fu0.25,0.50,0.75Interpretation
KB (epidermoid)72 h coexposure2.1, 1.82.2 ± 0.63 (P = 0.076)Antagonistic
A431 (epidermoid)72 h coexposure0.76 ± 0.095*0.69 ± 0.15 (P = 0.072)Weakly synergistic
SKOV-3 (ovarian)96 h coexposure0.53 ± 0.120.51 ± 0.12*Synergistic
IGROV-1 (ovarian)72 h coexposure0.50 ± 0.0260.45 ± 0.14*Synergistic
HX62 (ovarian)72 h coexposure4.6 ± 2.0*4.0 ± 0.87*Antagonistic
CH1 (ovarian)96 h coexposure3.0 ± 1.0*2.8 ± 0.47*Antagonistic
CH1Taxol (4 h) → 17-AAG (92 h)0.96 ± 0.0401.1 ± 0.33Additive
CH117-AAG (4 h) → Taxol (92 h)1.4, 1.91.8 ± 0.29*Antagonistic
  • NOTE: CI values given at fu0.50. The average CI is the average of the mean CI values at fu0.25,0.50,0.75. CI <1, synergy; CI >1, antagonism; CI ∼1.0, additivity.

  • * P < 0.05.

  • P < 0.005 (one sample, two-tailed t test compared with 1.0).