Table 1.

Inhibition of cell growth by paclitaxel and 17-AAG in four human ovarian and two epidermoid tumor cell lines

Cell lineInhibition of cell growth, IC50 (nmol/L)
Paclitaxel17-AAG
KB (epidermoid)40 ± 9.116 ± 1.5
A431 (epidermoid)36 ± 12383 ± 46
SKOV-3 (ovarian)65 ± 1366 ± 7.8
IGROV-1 (ovarian)43 ± 19343 ± 21
HX62 (ovarian)38 ± 9686 ± 62
CH1 (ovarian)6.3 ± 2.21,570 ± 310
  • NOTE: Cells were exposed to the agents continuously for 96 hours (CH1 and SKOV-3) or 72 hours (other lines) and growth inhibition was measured using the MTT assay as an end point. Results are given as mean ± SD (n ≥ 3).