Table 3.

Extent of inhibition of tumor neoangiogenesis by combined treatment with a VEGF receptor inhibitor (SU10944) and a PDGF receptor inhibitor (Gleevec) is similar to that seen with SU11248

Xenograft tumors (days of treatment)Carboxymethylcellulose
SU10944
Gleevec
SU11248
SU10944 + Gleevec
MVDMVD% InhPMVD% InhPMVD% InhPMVD% InhP
C6 (day 12)24.619.8200.1935.931.836.0
786-O (day 14)106.249.4540.03685.6190.2225.3760.02713.387NA
WM-266-4 (day 29)43.233.3230.1949.413.7680.00130.0310.034
H226 (day 14)74.243.2420.0976.28.4890.01221.2710.013
MV4;11 (day 15)46.928.1400.1286.1NANANA9.3800.015
  • NOTE: P, Student's t test (one-tailed distribution).

  • Abbreviations: MVD, average number of microvessels per 100× field. % Inh, percentage of inhibition of MVD in xenografts from treated animals compared with that of xenografts from vehicle-treated controls. NA, not applicable.