Table 3.

Inhibition of cell proliferation

Cell typeSourceGrowth factor*IC50 (nmol/L)
EndothelialHUAECVEGF0.2
Colon carcinomaHT-29FBS1,300
FibrosarcomaHT1080FBS6,800
Epidermoid carcinomaA431FBS3,200
Breast carcinomaMDA-435FBS2,400
Breast carcinomaMDA-231FBS>10,000
Small cell lung carcinomaH526FBS4,500
Colon carcinomaDLD-1FBS>10,000
Rat glioma9LFBS270
AML (FLT3-ITD)MV4-11FBS4.0
  • NOTE: Cells were incubated with ABT-869 for 72 hours.

  • * VEGF, 10 ng/mL; FBS, 10% fetal bovine serum.