Table 2.

Activity of ABT-869 in cellular receptor phosphorylation assays

CellReceptorLigandProtein*IC50 (nmol/L)
HUAECKDRVEGF2
3T3 transfectantsKDRVEGF4
Mouse plasma240
Human plasma340
3T3 transfectantsPDGFR-βPDGF-BB2
3T3 transfectantsKITVEGF31
3T3 transfectantsCSF-1RCSF-110
3T3 transfectantsTIE2Autoactivation3,500
  • * 50% mouse or human plasma.