Table 3.

Top 50 positive and negative correlations between array CGH and drug sensitivity for 118 “mechanism of action” compounds (with two-tailed 95% boostrap CIs)

LocusGene nameNSC No.DrugR*Lower 95% CI boundUpper 95% CI bound
BTKBruton agammaglobulinemia tyrosine kinase176323Camptothecin,9-MeO0.540.270.72
ZNF70Zinc finger protein 70 (Cos17)658831Taxol analogue0.530.240.74
CTSBCathepsin B153858Maytansine0.510.130.75
AFM267xd9658831Taxol analogue0.510.310.67
BRCA1Breast cancer 1, early onset109229l-Asparaginase0.500.320.66
FGFR3Fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)143095Pyrazofurin0.500.320.66
GPRK2LG protein–coupled receptor kinase 4143095Pyrazofurin0.500.320.66
276n12rev658831Taxol analogue0.490.280.66
TECTec protein tyrosine kinase143095Pyrazofurin0.490.260.68
EST_185259658831Taxol analogue0.490.230.68
ETV6ets variant gene 6 (TEL oncogene)167780Asaley0.480.280.73
LPLLipoprotein lipase49842Vinblastine-sulfate0.470.150.67
ETV6ets variant gene 6 (TEL oncogene)172112Spiromustine0.470.120.74
139k18rev658831Taxol analogue0.460.230.65
TCL1AT-cell leukemia/lymphoma 1A249992Amsacrine0.460.250.64
AFMa082zd9658831Taxol analogue0.460.240.63
191e05rev658831Taxol analogue0.460.220.65
ETV6ets variant gene 6 (TEL oncogene)34462Uracil mustard0.460.060.76
CDH1Cadherin 1, type 1, E-cadherin (epithelial)606985Camptothecin,20-ester (S)0.460.260.64
SHGC_6945658831Taxol analogue0.460.240.64
CDH1Cadherin 1, type 1, E-cadherin (epithelial)249992Amsacrine0.460.250.62
PRKCIProtein kinase C, ι176323Camptothecin,9-MeO0.460.120.67
S1B11_PRLL658831Taxol analogue0.460.200.65
PPP2R1BProtein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), β isoform143095Pyrazofurin0.450.190.64
CDH1Cadherin 1, type 1, E-cadherin (epithelial)94600Camptothecin0.450.240.63
ETV6ets variant gene 6 (TEL oncogene)664402Taxol analogue−0.45−0.77−0.01
ABRActive BCR-related gene118994Inosine-glycodialdehyde−0.45−0.63−0.21
AFM289zh5656178Taxol analogue−0.45−0.62−0.24
PTENPhosphatase and tensin homologue (mutated in multiple advanced cancers 1)330500Geldanamycin−0.45−0.64−0.21
PTENPhosphatase and tensin homologue (mutated in multiple advanced cancers 1)673187Taxol analogue−0.45−0.66−0.21
CCNCCyclin C671870Taxol analogue−0.46−0.71−0.15
CEBPBCCAAT/enhancer binding protein (C/EBP), β338947Clomesone−0.46−0.67−0.15
GADD45AGrowth arrest and DNA damage–inducible, α118994Inosine-glycodialdehyde−0.46−0.63−0.26
RETret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)656178Taxol analogue−0.46−0.65−0.21
CH1Chromosome 1 open reading frame 9118994Inosine-glycodialdehyde−0.46−0.63−0.26
ABCB1ATP-binding cassette, subfamily B (MDR/TAP), member 1666608Taxol analogue−0.46−0.70−0.03
AFM289zh5666608Taxol analogue−0.47−0.64−0.24
GRM3Glutamate receptor, metabotropic 3671867Taxol analogue−0.47−0.64−0.25
RARBRetinoic acid receptor, β600222Taxol analogue−0.47−0.66−0.20
PTENPhosphatase and tensin homologue (mutated in multiple advanced cancers 1)664404Taxol analogue−0.47−0.66−0.25
PTENPhosphatase and tensin homologue (mutated in multiple advanced cancers 1)664402Taxol analogue−0.47−0.68−0.22
SASSarcoma-amplified sequence656178Taxol analogue−0.47−0.64−0.23
RETret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)666608Taxol analogue−0.47−0.69−0.19
CCNCCyclin C666608Taxol analogue−0.48−0.76−0.12
ZNF70Zinc finger protein 70 (Cos17)107124Camptothecin,10-OH−0.48−0.69−0.19
GLIGlioma-associated oncogene homologue (zinc finger protein)656178Taxol analogue−0.49−0.65−0.24
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homologue (avian)153858Maytansine−0.50−0.65−0.31
AFMa303yb1600222Taxol analogue−0.51−0.69−0.26
ETV6ets variant gene 6 (TEL oncogene)671867Taxol analogue−0.56−0.76−0.18
ARHIras homologue gene family, member I118994Inosine-glycodialdehyde−0.57−0.71−0.42
  • * Pearson's correlation coefficient.