Clinical development of 1α,25(OH)2D3 and its analogues for cancer treatment
Study | Treatment | Patients | Protocol | Ref. |
---|---|---|---|---|
Phase II | 1α,25(OH)2D3 + dexamethasone | Prostate cancer before prostatectomy | Twice weekly p.o. | Ongoing study* |
Phase II | 1α,25(OH)2D3 + mitoxantrone + prednisone | Prostate cancer | High-dose pulse p.o. | Ongoing study* |
Phase II | 1α,25(OH)2D3 + docetaxel | Pancreatic cancer | Weekly p.o. | Ongoing study* |
Phase II | 1α,25(OH)2D3 | Prostate cancer before prostatectomy | Weekly p.o. | (98) |
Phase II | 1α,25(OH)2D3 + docetaxel | Prostate cancer | Weekly p.o. | (99) |
Phase II | 1α,25(OH)2D3 + carboplatin | Prostate cancer | Weekly p.o. | (100) |
Phase II | 1α(OH)D2 | Prostate cancer before prostatectomy | Daily p.o. | Ongoing study* |
Phase II | 1α(OH)D2 | Prostate cancer | Daily p.o. | (105) |
Phase II | EB1089 | Liver cancer | Daily p.o. | (103) |
Phase II | EB1089 | Pancreatic cancer | Daily p.o. | (104) |
Phase I | 1α,25(OH)2D3 + ketoconazole + dexamethasone | Advanced solid tumors | Days 1-3/wk p.o. | Ongoing study* |
Phase I | 1α,25(OH)2D3 + gefitinib + dexamethasone | Advanced solid tumors | Weekly i.v. | Ongoing study* |
Phase I/II | 1α,25(OH)2D3 + docetaxel + estramustine | Prostate cancer | High-dose pulse p.o. | (101) |
Phase I | 1α,25(OH)2D3 + paclitaxel | Advanced solid tumors | Days 1-3/wk p.o. | (95) |
Phase I | 1α,25(OH)2D3 | Liver cancer | Daily hepatic infusion | (97) |
Phase I | 1α,25(OH)2D3 | Advanced malignancy | Weekly p.o. | (94) |
Phase I | 1α,25(OH)2D3 | Advanced malignancy | Every other day s.c. | (93) |
Phase I | 19-Nor-1α,25(OH)2D2 + gemcitabine | Advanced malignancy | Weekly i.v. | Ongoing study* |
Phase I | 16-Ene-23-yne-1α,25(OH)2D3 | Advanced malignancy | Daily p.o. | (108) |
Phase I | 1α(OH)D2 | Prostate cancer | Daily p.o. | (106) |
Phase I | EB1089 | Breast and colorectal cancer | Daily p.o. | (102) |
No phase specified | 19-Nor-1α,25(OH)2D2 + zoledronate | Multiple myeloma or other plasma cell disorder | Weekly i.v. | Ongoing study* |
↵* Cancer clinical trial currently under way in the United States (http://www.cancer.gov).