Table 2.

Estimated coefficients ([thetas]p) in in vitro prediction formulae for IC50 (ln[IC50] = xi1[thetas]1 + xi2[thetas]2 + … + xip[thetas]p + εi)

CDDP
Paclitaxel
xip[thetas]pPxip[thetas]pP
Formulae using expression data of genes known as sensitivity determinants
    ln[IL6]−0.0690.133ln[ABCB1]
    ln[BCL2]−0.3930.0002
    ln[VEGF]0.834<0.0001
    ln[ERCC2]−0.3200.111
    εi5.482
Formulae using expression data of genes selected as novel markers
    ln[MYO5C]0.423<0.0001ln[TNFSF13B]0.0870.649
    ln[SPINK1]0.141<0.0001ln[IFIT3]0.6760.0001
    ln[ARMCX3]0.1330.011ln[BTN3A2]0.3230.180
    ln[PLEK2]−0.1240.105
    ln[PRSS11]−0.1260.0001
    εi6.262εi3.169
  • NOTE: Gene names inside brackets indicate the expression level of indicated gene.