Table 1.

Selected prediction marker genes

DrugGeneAccession no.Microarray
Real-time RT-PCR
Probability of heterogeneityrPrP
Genes known as sensitivity determinants
    CDDPIL6NM_0006000.806<0.0001
BCL2NM_0006330.782<0.0001
VEGFNM_0033760.4010.028
ERCC2NM_0004000.4030.027
    PaclitaxelABCB1NM_0009270.985<0.0001
Genes selected as novel markers
    CDDPMYO5CNM_0187281.000.964<0.010.6170.0003
SPINK1NM_0031220.980.865<0.010.6120.0003
ARMCX3NM_0166071.000.861<0.010.734<0.0001
PLEK2NM_0164451.000.810<0.010.5030.004
PRSS11NM_0027751.00−0.794<0.01−0.5170.004
    Paclitaxel
TNFSF13BNM_0065730.980.844<0.010.663<0.0001
IFIT3NM_0015490.940.806<0.010.769<0.0001
BTN3A2NM_0070470.920.773<0.010.5680.001
  • NOTE: We selected 8 novel genes as the most potent markers using a rank correlation analysis (P < 0.01) and a two-dimensional mixed normal model (PH > 0.8). All the selected prediction marker genes were confirmed in their correlation of expression level with drug sensitivity through quantitative real-time RT-PCR. —, not analyzed.