Table 1.

Examples of sequences of phage display–derived peptides that bind top1

Peptide name (clone from Fig. 1A)SequenceNumber of times appeared/no. cloned sequences
T1BP1 (clone 1)SSQVVGVPQLMQSSP1/5
T1BP2 (clone 2)SAYAATVRGPLSSAS1/5
T1BP3 (clone 6)DRVPLVHVIFNSFGY1/5
T1BP4 (clone 9)RNQGPVKMVFPIAPS1/5
T1BP5 (clone 10)EGQFTFPRGASE*1/5
  • NOTE: T1BP1 to T1BP5 were isolated from the third round of biopanning against a top1-DNA-9AC complex.

  • * EGQFTFPRGASE was truncated due to stop codon.