Table 6.

Common molecular targets whose levels negatively correlate with sensitivity to PIAs

GenePearson correlation coefficient
PIA5PIA6PIA23PIA24PIA25
CCNECyclin E−0.46−0.50−0.54−0.57
ERBB3ErbB3 (receptor protein-tyrosine kinase)−0.46−0.42−0.53−0.50
TFAP2ATranscription factor AP-2 alpha−0.49−0.47−0.61
DZIP3Zinc finger DAZ interacting protein 3−0.50−0.47−0.50
MPDZMultiple PDZ domain protein−0.48−0.42−0.54
PHF10PHD finger protein 10−0.46−0.40−0.40
UBL3Ubiquitin-like 3−0.40−0.56−0.48
PPT2Palmitoyl-protein thioesterase 2−0.41−0.42−0.41−0.50
RHOQRas homologue gene family, member Q−0.41−0.40−0.43
PRAMEPreferentially expressed antigen in melanoma−0.46−0.43−0.43−0.53
CHST10Carbohydrate sulfotransferase 10−0.45−0.41−0.44
MYH10Myosin, heavy polypeptide 10, nonmuscle−0.46−0.43−0.41−0.51
VAT1Vesicle amine transport protein 1 homologue (T. californica)−0.44−0.43−0.47
APLP1Amyloid beta (A4) precursor-like protein 1−0.43−0.44−0.41
USP6Ubiquitin-specific protease 6 (Tre-2 oncogene)−0.42−0.43−0.47
LAPTM4BLysosomal-associated protein transmembrane 4 beta−0.40−0.44−0.47
  • NOTE: Included are negatively correlated targets that were common to at least three PIAs (PCC less than or equal to −0.4).