Table 5.

Common molecular targets whose levels positively correlate with sensitivity to PIAs

GenePearson correlation coefficient
PIA5PIA6PIA23PIA24PIA25
KLF4Kruppel-like factor 4 (gut)0.600.620.550.48
DPP4Dipeptidylpeptidase 40.570.490.46
SLCO4A1Organic anion transporter SLC21A120.530.550.51
PRSS3Protease, serine, 3 (mesotrypsin)0.490.520.410.520.48
RGS2Regulator of G-protein signaling 2, 24 kDa0.470.470.550.41
AIM1Absent in melanoma 10.470.440.450.50
AKAP1A kinase (PRKA) anchor protein 10.440.480.47
MYCc-Myc0.420.440.450.470.47
HDAC1Histone deacetylase 10.500.400.51
ETS2V-ets erythroblastosis virus E26 oncogene homologue 20.450.480.50
MAN2A1Mannosidase, alpha, class 2A, member 10.530.540.47
SOX9SRY (sex determining region Y)-box 90.450.480.45
GUK1Guanylate kinase 10.440.410.470.570.41
NSEP1Nuclease sensitive element binding protein 10.420.410.46
  • NOTE: Included are positively correlated targets that were common across three or more PIAs (PCC more than or equal to 0.4).