Table 4.

Molecular targets whose levels in the NCI60 cell line panel correlate most negatively with PIA sensitivity

RankPCCGeneDescription
PIA51−0.50SMARCA3SWI/SNF–related, actin-dependent regulator of chromatin, subfamily a, member 3
2−0.50DZIP3Zinc finger DAZ interacting protein 3
3−0.49HRMT1L1HMT1 hnRNP methyltransferase-like 1 (Saccharomyces cerevisiae)
4−0.48MPDZMultiple PDZ domain protein
5−0.46CCNECyclin E
6−0.46PRAMEPreferentially expressed antigen in melanoma
7−0.46PHF10PHD finger protein 10
8−0.46MYH10Myosin, heavy polypeptide 10, nonmuscle
9−0.46ERBB3ErbB3 (receptor protein-tyrosine kinase)
10−0.45CHST10Carbohydrate sulfotransferase 10
PIA61−0.50CCNECyclin E
2−0.49TFAP2ATranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
3−0.47HRMT1L1HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae)
4−0.47DZIP3Zinc finger DAZ interacting protein 3
5−0.47SMARCA3SWI/SNF–related, actin-dependent regulator of chromatin, subfamily a, member 3
6−0.44APLP1Amyloid beta (A4) precursor-like protein 1
7−0.43USP6Ubiquitin-specific protease 6 (Tre-2 oncogene)
8−0.43VAT1Vesicle amine transport protein 1 homologue (Torreya californica)
9−0.43USP32Ubiquitin-specific protease 32
10−0.43PRAMEPreferentially expressed antigen in melanoma
PIA231−0.56UBL3Ubiquitin-like 3
2−0.54CCNECyclin E
3−0.53ERBB3ErbB3 (receptor protein-tyrosine kinase)
4−0.50RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1
5−0.49PTTG1IPPituitary tumor-transforming 1 interacting protein
6−0.47TFAP2ATranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
7−0.44LAPTM4BLysosomal-associated protein transmembrane 4 beta
8−0.43ERBB3V-erb-b2 erythroblastic leukemia viral oncogene homologue 3 (avian)
9−0.43PRAMEPreferentially expressed antigen in melanoma
10−0.43ELOVL2Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
PIA241−0.44STAT3Signal transducer and activator of transcription 3
PIA251−0.61TFAP2ATranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
2−0.57CCNECyclin E
3−0.54MPDZMultiple PDZ domain protein
4−0.53PRAMEPreferentially expressed antigen in melanoma
5−0.51MYH10Myosin, heavy polypeptide 10, nonmuscle
6−0.51DRPLADentatorubral-pallidoluysian atrophy (atrophin-1)
7−0.50PPT2Palmitoyl-protein thioesterase 2
8−0.50DZIP3Zinc finger DAZ interacting protein 3
9−0.50ERBB3ErbB3 (receptor protein-tyrosine kinase)
10−0.48UBL3Ubiquitin-like 3
  • NOTE: The COMPARE program was used to generate a list of molecular targets whose levels correlate with the −log(GI50) of the PIAs. Shown are the molecular targets with 10 most negative PCCs for each PIA.