Table 3.

Molecular targets whose levels in the NCI60 cell line panel correlate most positively with PIA sensitivity

PIA510.60KLF4Kruppel-like factor 4 (gut)
20.57DPP4Dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2)
30.54ETS2V-ets erythroblastosis virus E26 oncogene homologue 2 (avian)
40.53SLCO4A1Organic anion transporter SLC21A12
50.53MAN2A1Mannosidase, alpha, class 2A, member 1
60.49PRSS3Protease, serine, 3 (mesotrypsin)
70.49HDAC1Histone deacetylase 1
80.48CLDN4Claudin 4
90.47RGS2Regulator of G-protein signaling 2, 24 kDa
100.47AIM1Absent in melanoma 1
PIA610.62KLF4Kruppel-like factor 4 (gut)
20.55SLCO4A1Organic anion transporter SLC21A12
30.54MAN2A1Mannosidase, alpha, class 2A, member 1
40.52PRSS3Protease, serine, 3 (mesotrypsin)
50.50EBPEmopamil binding protein (sterol isomerase)
60.50HDAC1Histone deacetylase 1
70.49DPP4Dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2)
80.49PPARGPeroxisome proliferative activated receptor, γ
90.49HSPE1Heat shock 10-kDa protein 1 (chaperonin 10)
100.48SOX9SRY (sex-determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
PIA2310.49LRP8Low-density lipoprotein receptor-related protein 8, apolipoprotein e receptor
20.48ATRXAlpha thalassemia/mental retardation syndrome X-linked (RAD54 homologue)
30.47GUK1Guanylate kinase 1
40.47NUPL2Nucleoporin like 2
50.46PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1
60.46PTK2BPYK2 (protein tyrosine kinase)
70.45EPHA3EphA3 (ephrin receptor, tyrosine kinase)
80.45TXKTXK (protein tyrosine kinase)
90.45HAPLN1Hyaluronan and proteoglycan link protein 1
100.45AIM1Absent in melanoma 1
PIA2410.67STX1ASyntaxin 1A (brain)
20.59HAPLN1Hyaluronan and proteoglycan link protein 1
30.58PPIFPeptidylprolyl isomerase F (cyclophilin F)
40.58ANXA7Annexin A7
50.57GUK1Guanylate kinase 1
60.56CDKN2BCyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
70.55HOXB13Homeobox B13
80.55RGS2Regulator of G-protein signaling 2, 24 kDa
90.55NEFLNeurofilament, light polypeptide 68 kDa
100.55KLF4Kruppel-like factor 4 (gut)
PIA2510.51NUPL2Nucleoporin like 2
20.51HDAC1Histone deacetylase 1
30.50AIM1Absent in melanoma 1
40.50ETS2V-ets erythroblastosis virus E26 oncogene homologue 2 (avian)
50.49SLCO4A1Organic anion transporter SLC21A12
60.48RPS24Ribosomal protein S24
70.48PRSS3Protease, serine, 3 (mesotrypsin)
80.48KLF4Kruppel-like factor 4 (gut)
90.47MYCc-Myc (basic helix-loop-helix transcription factor family)
100.47AKAP1A kinase (PRKA) anchor protein 1
  • NOTE: The COMPARE program was used to generate a list of molecular targets whose levels correlate with the −log(GI50) of the PIAs. Molecular targets with the top 10 highest positive PCCs are shown for each PIA.