Table 2.

Comparison of sensitivity of PIAs to levels of phosphorylated and total Akt in the NCI60 cell line panel

PS473PT308Akt
PIA50.310.34−0.26
PIA60.280.31−0.31
PIA230.310.29−0.09
PIA240.30.24−0.1
PIA250.320.29−0.29
  • NOTE: The COMPARE program was used to generate Pearson correlation coefficients between the −log(GI50) of the PIAs and the levels of phospho-Akt (S473 and T308) and total Akt present in the cell lines as measured by immunoblot analyses. PCCs range from a value of 1.0 for a perfect match, to −1.0 for a perfect inverse match, with a value of 0, indicating no correlation between measurements.