Table 4.

Cytotoxicity of 5HPP-33 in paclitaxel-resistant 1A9 ovarian carcinoma cells

Drug1A9 Parental
PTX10
PTX22
IC50 (μmol/L)RRRR
5HPP-332.1 ± 0.11.10.7
Paclitaxel0.00115078
Paclitaxel*0.0022424
Vinblastine*0.00350.50.4
  • NOTE: All 5HPP-33 data are means of triplicate determination. RR = (ratio of the IC50 of the resistant cells) / (IC50 of the parental cells).

  • * The cytotoxicity of paclitaxel was tested at the same time and is shown compared with published data from ref. 35 for paclitaxel and vinblastine.