Table 1.

Pharmacokinetic variables of KRN633 crystal form and KRN633 solid dispersion in male rats after being given orally once at 3 mg/kg

VariableSolid dispersion, mean ± SD (n = 3)Crystal form, mean ± SD (n = 3)
Cmax,norm (μg/mL/mg/kg)2.29 ± 0.41*0.269 ± 0.09
Tmax (h)3.33 ± 1.154.00 ± 0.00
AUCnorm (μg h/mL/mg/kg)25.4 ± 2.10*3.38 ± 1.30
t1/2 (h)7.93 ± 2.386.84 ± 2.02
Bioavailability (%)65.8 ± 5.3*8.8 ± 3.3
  • * P < 0.05 (versus crystal form).