Table 1.

C35 expression in FFPE breast tissue sections was determined by immunohistochemistry

nHER-2/neu+ (%)C35+ (%)Mean C35 reactivityP (one-sample paired t)
Intraductal carcinoma
    Qualtek study572153
    AccuMax Array302040
    Asterand Array
71
20
38


    Total IDC15820*441.46<0.0001
    Low grade (1)220320.73
    High grade (2 and 3)3534662.03<0.0001
    Stage I2811180.93
    Stage II3824471.63<0.0001
    Stage III2619381.460.0035
    Stage IV425501.75
Lobular carcinoma
    Qualtek Study14050
    AccuMax Array4025
    Asterand Array
22
5
32


    Total ILC405381.160.0083
Papillary carcinoma: AccuMax813*501.13
Medullary carcinoma: Asterand600
Mucinous carcinoma: Asterand2050
Normal breast tissue
    Adjacent normal4013
    Normal breast1735
    Total normal breast57190.61
  • * All HER-2/neu+ samples are also C35+.

  • Significant difference compared with expression in normal breast by paired t test (P < 0.05).

  • The two HER-2/neu+ samples are C35.