Table 6.

5-FU plasma clearance function of the presence or absence or DPYD gene variants and clinical toxicity

SNPs5-FU clearance for patient with toxicity NCI grade (0-1-2)
5-FU clearance for patient with toxicity NCI grade 3 to 4
nMeanSDnMeanSD
IVS14 + 1G>Ah472.1144.62h454.3214.87
H1
2846A>Th489.684.82h660.7624.65
1679T>Gh0h141.06
85T>Ch130137.1351.02
H14137.6152.39H0
−1590T>C7128.4936.150
2983G>T00
295-298 del TCAT00
1156G>T00
2657G>A00
0 SNP found264136.3342.261978.6719.23
  • Abbreviation: NCI, National Cancer Institute.