Table 5.

Frequency of different SNPs in our population of 487 patients, frequency of IVS14 + 1G>A, A2846T, and T1679G in our extended population of 1,200 patients, and correlation with toxicity, any grade, and grade 3 to 4

SNPsPatients heterozygous/homozygous (of 487 patients)n (%) patients with 1 to 4 NCI grade toxicityn (%) patients with 3 to 4 grade toxicityPatients heterozygous/homozygous (of 1,200 patients), frequencyn (%) patients with 3 to 4 grade toxicity
IVS14 + 1G>A9/17 (70)6 (60)16/1 (1.3/0.1)11 (70)
2846A>T10/07 (70)6 (60)19/0 (1.6)13 (69)
85T>C150/1520 (12)11 (6.6)ND8 (5.5)
−1590T>C7/01 (14)0ND0
1679T>G1/01 (100)1 (100)2/0 (0.16)2 (100)
2983G>T0/0XXNDNA
295-298 del TCAT0/0XXNDNA
1156G>T0/0XXNDNA
2657G>A0/0XXNDNA
0 SNP found30033 (11)20 (6.6)NDNA
  • Abbreviations: NCI, National Cancer Institute; ND, not determined; NA, not applicable.