Table 4.

Grade distribution and characteristics of the early toxic side effects (cycles 1 and 2) in the population of patients

Toxicity grade
43210
Diarrhea11966
Neutropenia1181
H-F syndrome2341
Mucositis4271
Cardiac toxicity13
Nausea, vomiting212
All (no. patients), %20 (4)24 (5)14 (3)9 (2)421 (86)
Initial dose reduction (%)40, 1933, 33, 2520, 4850, 40, (35)3, (30)2, (25)2, (20)6, 15
  • NOTE: At the bottom of the table, the percentage of 5-FU dose reduction at the first cycle for medical reasons. (%)no. = no. patients when >1.