Table 1.

Inhibition of the proliferation of malignant hematopoietic cells by SU11248

Cell lineGene alterationsIC50 (μmol/L)
Eosinophilic leukemia
    EOL-1FIP1L1/PDGFRα0.004
Biphenotypic leukemia
    MV4-11FLT3-ITD0.025
Myeloid leukemia
    Kasumi-1Asn822Lys in c-Kit0.03
    U937Not achieved
    THP-13.5
    Kcl-22Bcr/Abl7.5
    K562Bcr/Abl3.5
    KU812Bcr/Abl2.5
Lymphoblastic leukemia
    PALL-1Bcr/Abl2.7
    PALL-2Bcr/Abl6
    NALL-15
Multiple myeloma
    U2668
Pleural effusion lymphoma
    KS-14
    BCBL-1Not achieved
Burkitt's lymphoma
    Akata5
    Daudi10
Adult T-cell leukemia
    MT-1Not achieved
    MT-2Not achieved
    MT-44
  • NOTE: IC50 of SU11248 was calculated from dose-response curves.