Table 2.

Cancer genes analyzed

Gene symbolGene nameNational Center for Biotechnology Information gene IDLikely oncogenic mutations*
APCAdenomatous polyposis coli3248
BRAFv-raf murine sarcoma viral oncogene homologue B167310
BRCA1Familial breast/ovarian cancer gene 16720
BRCA2Familial breast/ovarian cancer gene 26750
CDKN2ACyclin-dependent kinase inhibitor 2A, p16102933
CTNNB1Catenin (cadherin associated protein) β114991
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homologue 220640
HRASv-Ha-ras Harvey rat sarcoma viral oncogene homologue32651
EGFREpidermal growth factor receptor19560
FLT3fms-related tyrosine kinase 323220
KITv-KIT Hardy-Zuckerman 4 feline sarcoma viral oncogene homologue38150
KRASv-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue384511
MAP2K4Mitogen-activated protein kinase kinase 464160
METmet proto-oncogene42330
NRASNeuroblastoma RAS viral (v-ras) oncogene homologue48933
PDGFRAPlatelet-derived growth factor receptor, α polypeptide51560
PIK3CAPhosphoinositide-3-kinase, catalytic, α polypeptide52907
PTENPhosphatase and tensin homologue572811
RB1Retinoblastoma 159253
RETret proto-oncogene59790
SMAD4SMAD, mothers against DPP homologue 4 (MADH4)40892
STK11Serine/threonine kinase 11/LKB1 (Peutz-Jehgers syndrome)67944
TP53Tumor protein p53 (Li-Fraumeni syndrome)715741
VHLvon Hippel-Lindau tumor suppressor74282
  • * Mutations seen in common ancestor lines counted once.