Table 2.

Effect of INO-1001 on sensitivity to temozolomide

XenograftTemozolomide (fraction of LD10)INO-1001 (mg/kg)T-C (days)RegressionsDeaths
Experiment 1, D-245 MG (PR)0.7504.2*0 of 100 of 10
01000.50 of 100 of 10
01501.50 of 100 of 10
0.7510010.2*3 of 100 of 10
0.7515025.8*4 of 82 of 10
Experiment 2, D-245 MG (PR)0.7504.3*0 of 100 of 10
01501.40 of 100 of 10
0.7515013.9*3 of 91 of 10
Experiment 3, D-245 MG (PR)0.750−0.40 of 100 of 10
0200−2.00 of 100 of 10
0.7520012.9*4 of 73 of 10 (2 delayed deaths)
Experiment 4, D-245 MG (PR)0.50−1.00 of 80 of 8
02003.00 of 80 of 8
0.52005.5*0 of 90 of 9
Experiment 5, D-245 MG0.25043.1*10 of 100 of 10
0200−0.90 of 00 of 10
0.2520048.9*9 of 91 of 10
Experiment 6, D-245 MG0.25039.6*8 of 80 of 8
02002.30 of 80 of 8
0.2520045.7*10 of 100 of 10
  • * P ≤ 0.05.