Table 1.

Inhibition of PI3-Ks by PX-866 and wortmannin

PI3-KPX-866 IC50 (nm)Wortmannin IC50 (nm)
p110α/p85α5.54.0
p110β/p85α>3000.7
p120γ9.09.0
p110δ/p85α2.74.1
  • NOTE: Recombinant PI3-Ks were assayed for activity as described in the text.