Table 1.

Changes in expression of selected genes in CAPAN1 and CFPAC1 at 4 and 6 days after application of methionine stress

GeneSymbolChromosomeCAPAN1 methionineCAPAN1 homocysteineM/HCFPAC1 methionineCFPAC1 homocysteineM/H
Growth arrest and DNA damage inducible, βGADD45Bchr19p13.347.42,605.40.02546.5978.90.56
ClusterinCLUchr8p21-p1231610.20.05NENENE
SMAD, mothers against DPP homologue 7SMAD7chr18q21.130.1337.20.09410.8968.30.63
Breast cancer 1, early onsetBRCA1chr17q2131.6316.50.11125.5427.10.29
TGF, β-receptor-associated protein 1TGFBRAP1chr2q12.172.9648.90.11NENENE
v-ets erythroblastosis virus E26 oncogene homologue 2ETS2chr21q22.3|21q22.2105807.10.13615.9414.21.49
Protein (peptidyl-prolyl cis/trans isomerase) 1PIN1chr19p13102683.80.15NENENE
Insulin-like growth factor-binding protein 4IGFBP4chr17q12-q21.1185.71,113.80.17914.22,643.70.35
Sphingosine kinase 2SPHK2chr19q13.2139.3832.80.1762360.50.17
Neurofibromin 2NF2chr22q12.2131.7561.40.23364.6687.50.53
IFN, γ-inducible protein 16IFI16chr1q2275.6271.70.282,023.92,6530.76
Guanine nucleotide-binding protein (G protein)GNA11chr19p13.375265.10.28553.9639.50.87
Methionine adenosyltransferase II, αMAT2Achr2p11.23,776.712,193.40.311,368.73,525.90.39
Cyclin-dependent kinase inhibitor 2C (p18)CDKN2Cchr1p32278.4896.50.31148.2288.20.51
BH3-interacting domain death agonistBIDchr22q11.11,192.22,777.60.43640.11,499.70.43
Cyclin D1CCND1chr11q137921,404.20.561,0371,319.30.79
TGF-β-inducible early growth responseTIEGchr8q22.21,195.61,670.10.722,002.64,534.40.44
BCL2 antagonist of cell deathBADchr11q13.1646.4889.90.73594.7963.90.62
BCL2 antagonist/killer 1BAK1chr6p21.3525.2708.70.74640.9857.10.75
WEE1 homologue (Schizosaccharomyces pombe)WEE1chr11p15.3-p15.1463.7201.22.30709.4606.61.17
BUB1 budding uninhibited by benzimidazoles 1BUB1chr2q14727.92343.11320140.62.28
Cyclin B1CCNB1chr5q121,510.3453.43.33791.5336.92.35
Cell division cycle 2, G1-S and G2-MCDC2chr10q21.14171213.45616.1196.13.14
Ras homologue gene family, member BRHOBchr2p242,306.3618.93.735,804.24,537.31.28
Aurora kinase BAURKBchr17p13.1824.7209.13.94296.51781.67
Antigen identified by monoclonal antibody Ki-67MKI67chr10q25-qter143.733.64.28308.7516.05
Amphiregulin (schwannoma-derived growth factor)AREGchr4q13-q212,295.2518.44.432,725.8822.83.31
Fanconi anemia, complementation group LFANCLchr2p16.1459.795.84.80263.3230.41.14
Protein regulator of cytokinesis 1PRC1chr15q26.1615.6118.75.19762252.13.023
Cell division cycle 2-like 6 (CDK8-like)CDC2L6chr6q21578.7110.85.22284255.71.11
Thymidylate synthetaseTYMSchr18p11.322,251.8404.75.56360.2231.71.55
O6-methylguanine-DNA methyltransferaseMGMTchr10q26336.257.85.82404.843.39.34
Nucleolar and spindle-associated protein 1NUSAP1chr15q15.1726.2104.96.92523.53031.73
Cell division cycle associated 8CDCA8chr1p34.3513.555.19.32342.861.35.59
Topoisomerase (DNA) IIα 170 kDaTOP2Achr17q21-q221,280.492.313.871,457748.11.95
Cyclin B2CCNB2chr15q22.21,235.330.141.04759.6304.82.49
Colony-stimulating factor 2 (granulocyte-macrophage)CSF2chr5q31.1NENENE53.5727.10.07
Interleukin-6 (IFN, β2)IL6chr7p21NENENE1,819.73,530.20.52
Angiotensin II receptor, type 1AGTR1chr3q21-q25NENENE2,314.65833.97
  • NOTE: All changes listed are significant (P < 0.05). NE, not expressed: relative expression of <200 in both methionine and homocysteine sets.