Table 2.

Sensitivity of breast, ovarian, and prostate cancer cell lines to SC21, SC23, and CPT

Cell lineOriginHormone receptorp53pRbp16p21IC50 values (mean ± SD)*
SC21 (nmol/L)SC23 (nmol/L)CPT (nmol/L)
PC3prostateAR−nullWTWTWT3,250 ± 1062,000 ± 500900 ± 210
DU145prostateAR−MutnullMutMut120 ± 5050 ± 1925 ± 7
LNCaPprostateAR+WTWTWTWT200 ± 70850 ± 20025 ± 6
HEYovarianAR+WTNDWTND400 ± 602,350 ± 21235 ± 7
MCF-7breastER+WTWTWTWT40 ± 7280 ± 3530 ± 3
MDA-MB-435breastER−MutWTWTWT35 ± 7240 ± 2827 ± 2
MDA-MB-468breastER−MutnullNDWT200 ± 250 ± 14100 ± 2
  • Abbreviations: AR, androgen receptor; ER, estrogen receptor; WT, wild-type; Mut, mutated; ND, not determined.

  • * Cytotoxic concentration (IC50) is defined as drug concentration causing a 50% decrease in cell population.