Table 6.

Genes down-regulated in all seven data sets (two sets of HL60 exposed to 0.1 and 0.3 μmol/L SN-38, one set of HL60 cells following exposed to 1.0 μmol/L SN-38, one set of an AML patient following in vivotreatment with 10 mg/m2 CPT-11, and one set of a CML patient following in vivotreatment with 15 mg/m2 CPT-11)

NameCutoff value
≤ −0.5≤ −0.6≤ −0.7≤ −0.8≤ −0.9≤ −1.0
1Adenomatosis polyposis colixxxxxx
3Budding uninhibited by benzimidazoles 1 (yeast homologue)x
4Cyclic AMP–responsive element modulatorx
5CDC2, G1-S and G2-Mx
6Centromere protein E(312 kDa)xxxxxx
7Centromere protein F (350/400 kDa, mitosin)xxxx
8Cyclin A2xxxxxx
9Cyclin B2xxxxxx
10DEK oncogene (DNA binding)x
11Deleted in lymphocytic leukemia, 2xx
12H2A histone family member Lxxxx
13High-mobility group (nonhistone chromosomal) protein 17x
14Human SH3 domain–containing protein SH3P18 mRNA, complete cdsxx
15Hyaluronan-mediated motility receptor (RHAMM)xxx
16Inhibitor of DNA binding 2, dominant-negative helix-loop-helix proteinx
17MAD2 (mitotic arrest deficient, yeast, homologue)–like 1xxx
18Minichromosome maintenance deficient (S. cerevisiae) 4x
19NIMA (never in mitosis gene a)–related kinase 2x
20Nuclear receptor corepressor/histone deacetylase3 complex subunitxx
21Phosphodiesterase 4B, cyclic AMP–specific [dunce (Drosophila) homologuephosphodiesterase E4]x
22Protein phosphatase 3 (formerly 2B), catalytic subunit, αisoform (calcineurin Aα)x
23Topoisomerase (DNA) IIα(170 kDa)xxxxxx
24TRAF family member–associated nuclear factor-κB activatorx
25TTK protein kinasex
26Ubiquitin carrier protein E2-Cxxxxxx
27v-yes-1 Yamaguchi sarcoma viral oncogene homologue1x
28X-ray repair complementing defective repair in Chinese hamster cells 4x
  • NOTE: Six different threshold levels were used to assess how stringency would affect the number of genes down-regulated in all seven data sets.