Table 1.

Effect of oridonin on freshly isolated malignant lymphoid cells

Patient no.Age/sexDisease typeReduction in cell number (%control)
145/FATL (lymphoma)57
263/MATL (acute)72
381/FNHL (diffuse large, T)62
425/FALL (B)62
553/MNHL (diffuse large, B)60
664/MMM (IgA-κ)56
753/FMM (IgA-κ)59
866/MATL (lymphoma)39
953/FCLL (B)60
1070/FMM (IgG-κ)49
1137/FNHL (follicular, B)80
1275/FMM (IgA-κ)75
  • NOTE: Viable, freshly isolated lymphoid cells were enumerated by trypan blue exclusion after incubation for 2 days in enriched culture media either with or without oridonin (1 μg/mL).

  • Abbreviations: ATL, adult T-cell leukemia; ALL, acute lymphocytic leukemia; NHL, non-Hodgkin's lymphoma; CLL, chronic lymphocytic leukemia; T, T cell; B, B cell; M, male; F, female.