Table 3.

Biomarkers of tumor endothelial cell proliferation

Gene symbolRefSeq ID, H. sapiens (R. norvegicus)Gene/protein description
ANGPT2NM_001147 (XM_344544)Angiopoietin-2. A Tie-2 ligand that functions in vascular remodeling.
CLU (ApoJ)NM_001831 (NM_012679)Clusterin/apolipoprotein J. A secreted glycoprotein that associates with high-density lipoprotein that is implicated as both an antiapoptotic and an antiproliferative.
ENDRB (EtB)NM_000115 (NM_017333)Endothelin receptor type B. A G protein-coupled receptor that mediates endothelin-induced vasoconstriction via the nitric oxide synthesis pathway.
IFIT3 (GARG-49)NM_001549* (XM_220059)IFN-induced protein with tetratricopeptide repeats 3/GARG-49. Function unknown.
FUT4NM_002033 (NM_022219)Fucosyltransferase-4. An α1,3-fucosyltransferase implicated developmental function, it is involved in the synthesis of myeloglycan, the major physiologic ligand of E-selectin. It is highly expressed in some tumors with inverse correlation to prognosis.
PLAU (uPA)NM_002658 (NM_013085)Urokinase-type plasminogen activator. A serine-directed protease involved in vascular remodeling. It is a pro-tumor invasion and pro-metastasis factor.
  • * RefSeq ID for IFIT4, the most similar human protein (60% identity and 78% similarity).