Table 1.

Small molecule inhibitors of KDR

AssayKDR inhibitor A, IC50 (nmol/L)KDR inhibitor B, IC50 (nmol/L)
KDR412
KDR (rat)26
FLT1124251
FLT37279
FLT44541
FGFR15111,232
FGFR2106402
c-KIT28450
c-Fms20835
Platelet-derived growth factor receptor β5178
Human umbilical vascular endothelial cell mitogenesis1731
Rat endothelia cell mitogenesis32ND
Molecular structureEmbedded ImageEmbedded Image