Table 2.

Genes related to the sensitivity to MMC, vinorelbine, paclitaxel, and SN-38 in 42 human cancer cell lines

RankGeneGenbank IDrP
A. MMC
Sensitive
    1SF1D261210.5660.001
    2CBR3Ab0048540.4860.006
    3EMS1M983430.4800.010
    4JUNJ041110.4730.015
    5SFRS9U308250.4480.010
    6NMBRM734820.4280.012
    7RBMXZ230640.4190.012
    8SOD1M132670.4180.024
    9NOL1X555040.4150.025
    10PELP1U881530.4050.019
    11ARHAL250800.4040.030
    12AARSD320500.3980.018
    13NME1X176200.3980.032
    14HNRPA2B1M290650.3900.044
    15NME2L167850.3780.025
    16VAT1U180090.3760.031
    17SERPINB10U354590.3720.028
    18KIAA0436AB0078960.3530.041
    19DRPLAD318400.3500.049
    20MC3RL061550.3460.049
Resistant
    1SPTBN1M96803−0.4500.013
    2PET112LAF026851−0.4250.027
    3CAPN1X04366−0.4210.032
    4MELX56741−0.4140.028
    5PACEX17094−0.3800.035
    6DVL2AF006012−0.3700.034
    7LOC54543AJ011007−0.3660.022
    8PAPOLAX76770−0.3510.033
    9RPLP2M17887−0.3450.049
    10ARF4LL38490−0.3400.042
B. Vinorelbine
Sensitive
    1ARHAL250800.5340.003
    2NME2L167850.5210.001
    3VIL2X515210.4630.015
    4YWHAQX564680.4500.011
    5HK1M751260.4490.016
    6SATB1M972870.4390.006
    7CAMLGU182420.4390.007
    8CARSL068450.4330.007
    9CCNB1M257530.4270.013
    10U2AF1M969820.4240.022
    11PTMAM267080.4230.018
    12MLC1SAM312110.3970.022
    13NME1X176200.3930.035
    14SARSX912570.3860.032
    15CDC20U053400.3850.029
    16PPP4CX702180.3850.039
    17TNFAIP3M594650.3840.023
    18EEF1DZ215070.3840.023
    19PFKPD253280.3650.028
    20ENTPD2U915100.3650.037
    21CCL5M211210.3580.035
    22ACAT1D902280.3520.048
    23IQGAP1L330750.3510.042
    24PAX5M969440.3420.038
    25NRGNY096890.3360.042
    26K-α-1K005580.3280.048
    27NDUFB7M333740.3210.049
Resistant
    1HOXB1X16666−0.6000.000
    2F10K03194−0.5140.002
    3GPX2X53463−0.5090.002
    4NR1I2AF061056−0.4980.002
    5ANXA4M19383−0.4810.005
    6PDLIM1U90878−0.4650.006
    7LIPCX07228−0.4640.004
    8SERPINF2D00174−0.4470.004
    9HSD17B1M36263−0.4430.014
    10MAN2B1U60266−0.4400.008
    11LSSD63807−0.4300.014
    12PIK3CGX83368−0.4150.010
    13DBN1U00802−0.4140.017
    14NDUFA4U94586−0.4100.038
    15BDHM93107−0.3990.024
    16BCL2L1Z23115−0.3850.039
    17EEF1B2X60656−0.3830.030
    18F2V00595−0.3820.026
    19RARAX06614−0.3690.029
    20ITGB4X53587−0.3670.042
    21IMPA1X66922−0.3670.042
    22PACEX17094−0.3670.042
    23AGAM64073−0.3610.042
    24MVDU49260−0.3530.038
    25EHHADHL07077−0.3460.039
    26TFPI2D29992−0.3430.035
    27MARCKSM68956−0.3420.045
    28FGBJ00129−0.3340.035
    29GPD1L34041−0.3220.049
C. Paclitaxel
Sensitive
    1ADH6M688950.5130.002
    2RAB28X947030.4800.007
    3U2AF1M969820.4410.017
    4GPC1X542320.4400.013
5HK1M751260.4390.020
    6CARSL068450.4360.006
    7TNFAIP3M594650.4330.009
    8K-α-1K005580.4180.010
    9PFKPD253280.4160.012
    10GDI2D139880.4110.033
    11VIL2X515210.4100.034
    12RUNX2AF0014500.4090.038
    13NME2L167850.4070.015
    14CDC20U053400.3950.025
    15GNAI2X048280.3910.033
    16ARHAL250800.3810.041
    17CNR2X743280.3780.030
    18PPP2R2BM649300.3760.026
    19SLC6A8L314090.3740.046
    20DDX9L138480.3740.042
    21ACAT1D902280.3690.038
    22PI3Z185380.3290.047
Resistant
    1NAP1L1M86667−0.5300.004
    2HOXB1X16666−0.5160.004
    3PACEX17094−0.5070.004
    4MAN2B1U60266−0.4860.003
    5GPX2X53463−0.4800.004
    6DBN1U00802−0.4690.006
    7ANXA4M19383−0.4680.007
    8SERPINF2D00174−0.4630.003
    9AGAM64073−0.4440.011
    10BCL2L1Z23115−0.4280.021
    11LIPCX07228−0.4010.015
    12BDHM93107−0.3930.026
    13LSSD63807−0.3840.030
    14PDLIM1U90878−0.3720.033
    15ZNF161D28118−0.3680.038
    16UBE2E1X92963−0.3630.032
    17TLE1M99435−0.3600.039
    18RARAX06614−0.3590.034
    19PTPRNL18983−0.3570.035
    20APOEM12529−0.3530.048
    21F10K03194−0.3480.040
    22NR1I2AF061056−0.3420.041
    23UBE2L3X92962−0.3320.045
    24FGBJ00129−0.3130.049
D. SN-38
Sensitive
    1EMS1M983430.5730.001
    2JUNJ041110.5640.003
    3IL-6X046020.5140.003
    4RPL23X528390.4950.004
    5CDKN3L258760.4550.017
    6RPL3X734600.4450.011
    7TFPIJ032250.4420.009
    8MRPL3X063230.4370.009
    9HLA-CM118860.4240.014
    10AARSD320500.4190.012
    11ARHGDIAX695500.4160.031
    12NOL1X555040.4060.029
    13SF1D261210.3940.031
    14SOD1M132670.3890.037
    15VEGFM329770.3840.043
    16EIF2S1J026450.3820.034
    17CDH5X799810.3720.030
    18FOSL1X167070.3710.047
    19IDSM583420.3660.047
    20PMVKL772130.3640.044
    21PPP2CBX126560.3640.041
    22NMBRM734820.3620.035
    23RPL26X693920.3580.035
    24PELP1U881530.3560.042
    25MC3RL061550.3560.042
    26RPS8X672470.3550.036
Resistant
    1CAPN1X04366−0.4960.010
    2MELX56741−0.4780.010
    3PACEX17094−0.4430.012
    4TIMP2J05593−0.4330.019
    5AOP2D14662−0.4220.025
    6ZNF174U31248−0.4020.018
    7ID3X69111−0.3930.038
    8KLF5D14520−0.3840.036
    9CALD1M64110−0.3820.031
    10LOC54543AJ011007−0.3680.021
    11PTPN3M64572−0.3630.038
    12ACTBX00351−0.3620.025
    13LY6EU42376−0.3600.037
    14ID1D13889−0.3430.044
  • NOTE: Column 2 shows the name of the gene according to HUGO database. Column 4 shows Pearson correlation coefficient between chemosensitivity to drugs and gene expression. “Sensitive” indicates candidate genes sensitive to each drug. “Resistant” indicates genes resistant to each drug.