Table 1.

The mode of actions and the median value of ∣log10GI50∣ of 53 anticancer drugs in each of the 45 cell lines

Drug nameTarget/mode of actionBreast
Liver
Stomach
HBC-4BSY1HBC-5MCF-7MDA-MB-231KPL-3CKPL-4KPL-1T-47DHBC-9ZR-75-1HBC-8HepG2Hep3BLi-7PLC/PRF/5HuH7HLEHLFHuH6RBESSP-25HuL-1JHH-1St-4MKN1MKN7MKN28MKN45MKN74GCIYGT3 TKBHGC27AZ5214-1STNUGC -3NUGC -3/5-FUHSC-42AGSKWS-1TGS-11OKIBAISt-1ALFAOTO
AclarubicinDNA/RNA synthesis7.048.697.927.867.837.117.637.957.397.088.037.938.137.777.397.688.297.497.867.707.877.397.978.237.888.097.737.258.597.438.007.867.138.497.969.047.518.218.277.968.317.207.198.547.57
OxaliplatinDNA cross-linker5.795.755.405.694.755.045.204.785.174.105.086.177.075.395.785.616.444.904.755.605.194.586.046.014.755.044.424.586.844.935.715.315.106.165.176.185.235.985.586.267.025.855.145.464.78
Actinomycin DRNA synthesis9.209.108.859.458.718.909.059.048.898.248.989.609.038.618.248.048.998.138.458.758.258.478.789.007.998.748.779.029.399.208.249.128.769.558.808.858.569.328.999.229.559.358.779.398.88
HCFUPyrimidine4.365.174.445.134.574.655.554.414.974.224.684.845.284.804.794.564.994.674.704.504.924.694.874.634.174.704.824.775.564.864.775.094.745.214.844.744.364.895.004.714.275.104.154.234.44
5-FUPyrimidine4.434.874.405.124.184.005.234.004.134.004.705.115.274.204.264.215.084.004.194.004.604.005.294.724.354.404.264.275.464.224.605.094.345.124.044.674.004.405.024.504.066.384.004.424.09
DoxifluridinePyrimidine4.004.424.004.004.004.004.094.004.004.004.144.194.494.004.004.004.004.004.004.004.004.004.044.004.004.004.014.004.204.004.004.004.004.004.004.024.004.004.264.004.004.184.004.004.00
E7070Cell cycle inhibitor4.506.204.224.504.354.945.014.744.694.004.384.985.474.994.774.445.364.614.434.745.094.294.294.874.436.034.905.484.555.205.044.825.696.024.885.754.394.814.465.254.966.054.836.694.97
TamoxifenEstrogen receptor4.955.425.015.044.905.145.494.935.314.904.955.535.455.305.234.795.095.024.975.384.905.114.874.974.954.895.445.235.135.674.925.195.255.114.875.064.864.895.594.935.205.584.935.435.13
ToremifeneEstrogen receptor4.815.124.874.964.854.935.134.885.174.894.884.865.064.974.924.824.995.094.914.954.925.004.805.104.814.924.904.824.935.234.854.925.075.094.874.964.854.885.004.935.075.584.885.505.24
MS-247DNA synthesis6.086.795.326.785.986.096.165.866.636.426.886.716.335.846.355.236.026.586.425.825.666.375.676.825.665.726.275.597.326.625.716.886.767.587.096.625.647.117.016.746.676.205.705.705.63
DaunorubicinDNA synthesis/topo II6.967.346.827.686.836.777.256.847.416.927.397.977.487.106.836.397.297.557.496.987.186.737.087.516.607.306.987.037.666.886.797.557.177.987.187.746.857.577.426.996.937.596.376.946.80
DoxorubicinDNA synthesis/topo II7.137.266.857.586.666.747.386.767.366.947.127.857.296.776.885.837.047.397.256.876.896.686.897.316.397.456.796.717.326.706.397.146.867.876.687.666.477.337.536.916.908.006.016.346.54
EpirubicinDNA synthesis/topo II6.086.906.597.086.426.507.036.837.266.737.907.197.336.866.876.297.317.217.256.916.846.736.747.037.217.536.856.607.356.606.537.106.718.007.027.686.137.618.027.126.917.125.997.006.51
MitoxantroneDNA synthesis6.287.126.008.066.506.406.836.387.116.968.027.447.956.517.886.516.767.607.676.717.377.596.117.156.827.526.576.527.796.686.877.826.838.797.387.596.187.707.757.216.748.565.766.146.37
PirarubicinDNA synthesis/topo II8.979.008.349.008.478.629.008.399.008.229.009.009.008.589.008.269.009.009.008.598.989.008.959.008.318.978.558.579.008.538.819.008.569.008.869.008.659.009.008.998.588.818.168.688.57
TopotecanTopo I5.846.575.108.005.556.376.715.907.516.187.207.617.935.817.705.646.077.737.735.726.836.745.306.997.216.275.545.818.005.626.617.835.647.748.007.685.828.007.546.076.396.106.706.906.85
SN-38Topo I7.987.525.568.566.126.757.406.608.256.137.927.758.436.378.216.036.758.288.315.917.057.475.697.746.836.636.166.168.716.176.898.496.048.498.788.286.318.618.706.816.667.077.297.467.28
CamptothecinTopo I5.926.576.047.635.866.676.606.707.125.807.216.927.446.197.485.866.357.427.536.106.696.796.166.927.136.395.825.507.995.626.817.535.497.617.757.736.007.767.236.366.646.816.436.726.96
BleomycinDNA synthesis4.814.894.004.484.004.005.594.005.464.464.224.376.024.385.664.004.856.046.594.154.734.975.104.944.004.614.034.004.544.224.006.214.227.186.034.754.005.665.194.004.005.554.004.814.58
PeplomycinDNA synthesis4.905.844.005.224.274.616.294.085.374.524.725.256.734.726.404.455.465.866.564.015.125.835.355.344.004.804.564.095.184.824.395.964.687.326.164.924.056.005.824.654.085.924.235.044.78
NeocarzinostatinDNA synthesis7.358.006.038.176.556.427.616.187.267.067.268.108.226.727.816.346.927.607.806.577.277.536.677.096.176.926.586.478.387.196.957.746.928.587.598.006.547.897.786.846.607.056.546.747.24
IrinotecanTopo I4.865.094.005.464.284.304.914.115.214.154.475.245.184.365.614.004.335.255.134.114.374.644.054.784.004.414.294.025.414.264.445.244.005.585.395.414.065.485.504.254.584.644.424.564.71
TAS103Topo6.817.226.377.666.576.457.206.177.256.167.137.607.566.577.686.646.957.817.876.557.326.896.956.945.757.546.506.567.506.436.967.976.818.517.407.766.457.667.986.946.456.896.246.457.74
GemcitabinePyrimidine6.745.624.008.005.204.007.254.007.185.154.715.758.004.638.004.006.167.838.004.196.567.245.605.854.096.174.454.008.005.386.187.574.008.006.687.704.006.776.654.004.066.764.865.827.27
CladribinePyrimidine4.004.004.005.414.054.604.734.004.834.234.004.686.304.004.864.004.005.855.454.004.865.304.004.004.114.514.004.006.884.004.005.564.006.524.435.424.004.464.564.004.006.414.004.004.24
CytarabinePyrimidine4.004.004.006.404.004.005.024.004.004.004.004.546.224.004.004.004.005.225.414.004.004.004.004.004.004.004.004.006.414.004.006.384.006.565.685.764.005.965.604.004.007.324.005.584.00
EtoposideTopo II4.885.484.396.154.664.005.424.685.934.485.114.725.624.865.564.604.925.805.705.054.855.355.355.094.675.794.594.515.434.224.965.555.226.235.805.904.726.116.135.134.418.004.735.105.79
AmsacrineTopo II5.205.785.296.565.254.895.694.935.975.146.565.706.415.566.665.475.776.586.615.435.905.985.715.465.306.245.014.966.435.345.756.555.506.986.446.684.916.536.305.714.996.605.065.576.29
2-DimethylaminoetoposideTopo II4.674.824.026.024.484.005.034.005.054.895.744.715.564.665.704.544.735.755.844.575.205.544.754.664.705.634.574.375.674.294.975.755.055.995.726.144.125.945.174.784.366.254.574.805.75
NK109Topo II5.695.885.276.376.045.496.315.566.305.576.085.816.565.966.725.856.056.836.775.846.246.395.926.096.026.665.885.766.515.626.586.926.296.906.666.785.956.706.476.635.687.275.795.916.86
MMCDNA alkylator5.906.685.686.995.145.466.405.505.425.495.746.696.565.047.095.635.736.156.315.385.326.205.505.994.935.005.335.107.095.565.756.175.746.455.997.285.586.276.235.865.755.565.326.035.86
MethotrexateDHFR7.115.194.007.534.004.007.535.254.004.004.004.007.474.006.114.006.126.646.834.006.714.064.005.137.277.044.004.007.154.007.067.047.497.377.337.324.007.387.537.814.006.664.004.004.00
RadicicolHSP90/Tyr kinase5.555.805.177.286.555.196.135.287.435.396.186.627.877.086.436.166.466.636.836.035.525.615.945.686.966.595.885.666.446.156.406.896.006.637.426.085.717.637.076.786.806.805.766.386.74
VinblastineTubulin9.229.769.229.688.679.179.779.139.156.007.587.998.186.509.307.739.359.739.207.226.009.519.119.666.179.627.609.649.049.258.589.889.379.769.859.538.209.859.699.809.289.717.048.128.33
VincristineTubulin8.779.729.299.428.679.129.579.319.226.008.416.207.936.007.706.008.528.768.406.006.008.278.389.116.379.368.608.588.429.138.129.308.919.369.618.947.129.709.249.359.4110.006.007.468.20
VinorelbineTubulin8.459.238.518.858.238.339.358.938.416.008.166.007.986.008.156.008.438.758.287.056.008.518.659.216.008.608.518.598.428.537.969.228.378.898.838.877.139.328.868.878.589.796.008.258.64
PaclitaxelTubulin7.308.437.947.727.377.388.207.537.906.007.056.597.356.847.416.487.447.507.276.006.737.808.227.946.877.687.507.487.897.166.778.157.708.097.868.156.498.077.747.968.038.296.527.797.52
DocetaxelTubulin8.418.988.238.527.888.188.828.198.566.007.158.288.087.117.836.808.238.098.086.006.148.508.548.507.058.068.108.328.477.716.938.858.199.088.508.517.218.868.638.478.498.467.338.688.27
Dolastatine 10Tubulin9.1510.8311.1910.269.0710.0210.749.449.958.009.468.6710.428.9410.719.5010.1210.199.948.608.0010.309.6810.619.419.5610.2710.189.7510.2910.5110.609.2310.4210.5310.358.8910.6910.5010.4410.1311.868.6910.0910.26
ColchicineTubulin6.068.686.336.487.247.588.487.896.645.007.846.597.165.407.256.437.627.777.395.545.007.507.458.177.767.997.287.907.757.517.347.787.657.708.697.535.988.598.198.347.458.746.057.567.84
E7010Tubulin4.376.564.006.145.075.386.695.716.295.506.044.726.284.626.386.236.356.476.354.794.006.506.446.506.066.216.266.356.026.156.396.696.086.696.676.404.376.696.476.646.276.884.515.505.36
MelphalanDNA cross-linker4.204.924.425.094.334.674.044.664.384.084.454.574.764.474.624.004.444.594.814.034.394.404.844.864.474.704.194.004.794.364.554.594.725.185.265.324.565.345.274.005.004.624.154.734.67
Leptomycin BCell cycle inhibitor9.359.649.339.448.919.599.479.639.268.969.789.749.679.329.449.199.109.319.379.009.299.519.549.669.459.449.369.259.459.509.159.489.579.819.699.549.129.649.538.669.169.718.829.769.49
CarboplatinDNA cross-linker4.004.344.124.004.004.004.004.004.004.004.004.004.184.004.004.004.004.004.004.004.004.004.004.534.004.254.004.004.004.004.004.144.004.004.244.974.004.364.164.004.004.624.004.004.26
CisplatinDNA cross-linker4.905.695.655.094.564.725.524.634.565.354.715.395.535.325.514.755.635.365.455.264.734.945.415.864.785.615.074.665.474.485.355.464.755.125.606.524.805.645.554.745.715.795.435.575.51
4-HydroperoxycyclophosphamideDNA alkylator4.784.855.415.584.684.784.544.744.865.184.764.784.924.744.884.654.844.875.044.824.694.904.765.304.374.774.814.925.134.764.854.814.805.305.255.334.785.505.444.704.685.174.614.664.78
6-MercaptopurinePurine5.414.734.155.885.175.114.505.026.004.274.054.505.014.105.124.424.004.174.494.905.294.584.825.104.215.584.675.215.395.864.455.215.475.545.975.035.195.905.864.954.554.854.004.004.00
6-ThioguaninePurine4.595.855.405.865.805.925.555.915.814.535.215.665.084.575.235.374.704.225.146.045.765.185.926.146.186.135.495.465.665.745.835.575.836.216.535.365.506.545.615.795.926.104.004.464.36
L-AsparaginaseProtein synthesis6.556.634.006.436.016.037.206.186.105.496.076.366.404.788.006.494.006.916.634.006.358.006.614.426.326.416.646.546.656.915.306.705.786.726.346.516.636.476.936.514.946.524.005.564.00
EstramustineEstradiol4.094.514.004.004.664.854.564.314.174.744.004.734.004.004.274.244.054.374.034.104.144.184.094.144.214.264.004.004.204.724.294.454.344.205.114.484.085.034.744.424.024.794.594.954.76
IFN-αBiological response4.007.714.004.004.234.004.004.004.004.004.005.024.004.004.204.004.004.004.004.004.004.004.004.004.004.004.004.004.004.514.004.004.004.004.004.004.004.004.004.004.514.204.624.624.16
IFN-βBiological response4.008.004.004.006.404.237.084.004.004.004.004.564.004.007.156.174.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.006.024.934.776.286.54
IFN-γBiological response7.697.934.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.007.934.004.074.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.004.005.064.00