Table 1.

Genes regulated in expression by curcumin

DescriptionFold increase
Human mRNA encoding the c-myc oncogene2
Homo sapiens Kruppel-like zinc finger protein Zf9 mRNA2
HUMMKK3A H. sapiens MKK3 mRNA2
HUMPAIA Human, plasminogen activator inhibitor-1 gene2
H. sapiens mRNA for dual-specificity phospatase MKP-52
H. sapiens H4/e gene for H4 histone/cds2.3
Human-soluble CD44 (CD44) mRNA, with exon v9 extension2.5
Human mRNA for Arg-Serpin (plasminogen activator-inhibitor 2)2.5
H. sapiens mRNA for histone H2B2.5
Human mRNA for MKK3b2.6
Human wild-type p53 activated fragment-1 (WAF1) mRNA2.6
Human cyclin-dependent kinase inhibitor p27kip1 mRNA3.2
Transferrin (human, liver, mRNA)3.2
Human c-jun proto-oncogene (JUN)3.2
H. sapiens mRNA for urokinase plasminogen activator receptor/cds3.5
Human mRNA for stromelysin3.5
Human ATF3 mRNA4.6
Human mRNA for metalloproteinaise stromelysin-24.9
Human cellular oncogene c-fos13.9
HSCL100 H. sapiens CL100 mRNA for protein tyrosine phosphatase19.6
H. sapiens antagonizer of myc transcriptional activity (Mad) mRNA68.5
  • NOTE: Total RNA was extracted from MDA-1986 squamous cell carcinoma cells treated with or without 50 ╬╝mol/L curcumin for 8 hours. Gene expression profiling was performed using the HGU95Av2 array (Affymetrix). Genes increased in their expression >2-fold are indicated together with the respective fold change.