Table 1.

Highly overexpressed genes in PTCL-NOS compared with normal peripheral blood T cells or lymph node

Fold ΔGene nameFunction
PTCL-NOS vs normal peripheral blood T cells: top increases
176COL1A1ECM
154CCL18Chemokine
135CXCL13Chemokine
130IGFBP7Proliferation
128RARRES1Tumor suppression
123CLUECM
109C1SECM
107FN1ECM
103CTGFProliferation
102CCL2Chemokine
101LUMECM
99SERPING1Protease inhibition
99APOC1Lipid metabolism
98NIDECM
96COL1A2ECM
94TEM6Angiogenesis
93COL3A1ECM
89APOELipid metabolism
89UBDProtein degradation
89PLTPLipid metabolism
88CD14Antiapoptosis
PTCL-NOS vs normal lymph node: top increases
200CHI3L1ECM
154CCL18Chemokine
120CCL5Chemokine
120SH2D1AProliferation
120NKG7Natural killer receptor
113HLA-DQB1Immune regulation
109FLI1Oncogene
108AIF1Proliferation
108CORO1ACytoskeleton
107RAC2Proliferation
106MAP4K1Proliferation
104PSMB8Proteasome
104TCRγT-cell receptor
102CARD15Apoptosis
100LYZECM
100TRIMInflammation
100CRIP1Proliferation
96CDW52Proliferation
92TCRβT-cell receptor
89UBDProtein degradation
89PPP1R16BProtein phosphatase